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The cause of stroke in people with Covid-19 disease

 

A neurologist said that the risk of stroke in people with Covid-19 even threatens young people. The coronavirus enters the body through the mouth and nose in the first stage, and at this stage the loss of taste and smell is one of the first signs of the virus.In the next stage, the virus that enters from the mouth and nose can reach the central nervous system and the brain, and the occurrence of encephalitis is one of the complications of the coronavirus in the patient’s nervous system.

“Unfortunately, these viruses have been shown to be more common in people who have no underlying disease,” said the neuroscientist. We expected a vascular and coagulation system conflict after corona in people with high blood pressure, blood sugar and blood lipids, but we see that people with no underlying disease have these secondary problems after corona have suffered.

Even young people are no exception, and coronary heart disease has been shown to cause coronary heart disease. Together, what is important is the speed with which the patient is delivered to the medical center and the patient is monitored to minimize the effects of stroke.

“The behavior of the virus is not yet predictable for us, and caution in social behavior and adherence to health practices must be taken seriously by people,” the neurologist said.

The most common cause of death in coronary heart disease is lung disease,” said a cardiovascular specialist. “Lung involvement with the covid-19 virus can cause heart failure.” Coronary heart disease in a person with a healthy heart can involve small blood vessels, or micro-vascularization (destruction of small blood vessels such as capillaries) and coronary arteries, or coronary arteries (heart vessels). Covid-19 disease can cause atrial fibrillation and right ventricular failure, and due to involvement of the lungs, right atrium and right ventricle can cause heart failure. The virus can also cause inflammation of the heart muscle, or myocarditis. Inflammation of the heart muscle, or myocarditis, is very dangerous; Because it leads to the destruction or death of the heart muscle cells.

 

How can cardiovascular patients protect themselves against corona in quarantine?

 

A member of the faculty of Zanjan University of Medical Sciences said: “Cardiovascular patients should regularly and continuously take their medications and not forget about physical activities such as walking and light sports.” Noting that people with terrestrial diseases such as cardiovascular disease and kidney disease are more vulnerable to coronavirus, 40% of patients with coronary heart disease in China had cardiovascular disease, indicating a worsening of the disease and a threat to their health and lives.

There is more concern about cardiovascular disease in patients with Covid-19 disease. When a person suffers from pulmonary embolism, due to the burden on the heart, the heart’s efforts to get better and more oxygen cause the heart to overheat and aggravate cardiovascular disease, and people who have had heart failure in the past cannot do well on their own.

Some patients are relieved that their heart rate should be reduced as they quarantine their activity, and that they need to reduce and discontinue the medication. Cardiologists are strongly opposed to reducing medication because they reduce their activity in the short term. But reducing long-term activity can be costly for them; Therefore, it is recommended to walk even in their homes so that they are a few minutes away from lying down and sitting.


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June 30, 2020 — A new study shows that SARS-CoV-2, the virus that causes COVID-19 (coronavirus), can infect heart cells in a lab dish, indicating it may be possible for heart cells in COVID-19 patients to be directly infected by the virus. The discovery, published today in the journal Cell Reports Medicine, was made using heart muscle cells that were produced by stem cell technology.

Although many COVID-19 patients experience heart problems, the reasons are not entirely clear. Pre-existing cardiac conditions or inflammation and oxygen deprivation that result from the infection have all been implicated. But until now, there has been only limited evidence that the SARS-CoV-2 virus directly infects the individual muscle cells of the heart.

“We not only uncovered that these stem cell-derived heart cells are susceptible to infection by novel coronavirus, but that the virus can also quickly divide within the heart muscle cells,” said Arun Sharma, Ph.D., a research fellow at the Cedars-Sinai Board of Governors Regenerative Medicine Institute and first and co-corresponding author of the study. “Even more significant, the infected heart cells showed changes in their ability to beat after 72 hours of infection.”

The study also demonstrated that human stem cell-derived heart cells infected by SARS-CoV-2 change their gene expression profile, further confirming that the cells can be actively infected by the virus and activate innate cellular “defense mechanisms” in an effort to help clear out the virus.

While these findings are not a perfect replicate of what is happening in the human body, this knowledge may help investigators use stem cell-derived heart cells as a screening platform to identify new antiviral compounds that could alleviate viral infection of the heart, according to senior and co-corresponding author Clive Svendsen, Ph.D.

“This viral pandemic is predominately defined by respiratory symptoms, but there are also cardiac complications, including arrhythmias, heart failure and viral myocarditis,” said Svendsen, director of the Regenerative Medicine Institute and professor of Biomedical Sciences and Medicine. “While this could be the result of massive inflammation in response to the virus, our data suggest that the heart could also be directly affected by the virus in COVID-19.”

Researchers also found that treatment with an ACE2 antibody was able to blunt viral replication on stem cell-derived heart cells, suggesting that the ACE2 receptor could be used by SARS-CoV-2 to enter human heart muscle cells.

“By blocking the ACE2 protein with an antibody, the virus is not as easily able to bind to the ACE2 protein, and thus cannot easily enter the cell,” said Sharma. “This not only helps us understand the mechanisms of how this virus functions, but also suggests therapeutic approaches that could be used as a potential treatment for SARS-CoV-2 infection.”

The study used human induced pluripotent stem cells (IPSCs), a type of stem cell that is created in the lab from a person’s blood or skin cells. IPSCs can make any cell type found in the body, each one carrying the DNA of the individual. Tissue-specific cells created in this way are used for research and for creating and testing potential disease treatments.

“This work illustrates the power of being able to study human tissue in a dish,” said Eduardo Marbán, MD, Ph.D., executive director of the Smidt Heart Institute, who collaborated with Sharma and Svendsen on the study. “It is plausible that direct infection of cardiac muscle cells may contribute to COVID-related heart disease.”



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By Mutrana . All rights reserved.



By Mutrana . All rights reserved.